Cadenza 5CX-C18

Conventional ODS columns, including hybrid-silica type columns, require extensive end-capping in order to decrease residual silanols, which may negatively affect peak shape for basic compounds. Traditionally, this end-capping process has used methyl silane compounds which have a mild hydrophobic interaction. Viewing this interaction in terms of reversed-phase mode, the surface of the stationary phase presents two very different kinds of hydrophobic structures, octadecyl ligands(C18) and the methyl end-capping. These different hydrophobicities may provide an inconsistent response against a solutes interaction with the stationary phase, resulting in poor peak shape and reduced plate counts. Instead of relying on traditional end-capping with trimethyl silane (TMS) compounds, we have succeeded to develop a revolutionary surface modification technology using alcohol structures, which has been adapted to our brand new Cadenza 5CX-C18. This means that electrostatic interaction from the polar end-capped surface and hydrophobic interaction from the C18 ligand will localize the polarity of the surface and increase the recognition power of a complex compounds hydrophobic/hydrophilic structure. Therefore, Cadenza 5CX-C18 will have an alternative selectivity for certain compounds and possibly improved peak shape compared to conventional end-capped ODS columns.
 

• Our first column featuring modified alcohol polar end-capping
• Nearly 100% coverage of active surface silanol sites
• Reduces tailing for basic compounds in acidic conditions
• Alternative selectivity from traditional C18 columns
• High steric selectivity and molecular recognition
• Ideal for difficult isomer or impurity separations