High-Performance ODS Column with Unique End-Capping
FEATURES
World-class Theoretical Plate Number Column with 50,000 Plates (250x4.6mm)
High Separation Performance: Separation of analogs and isomers
Unique End-Capping: Resistant to bases, acids, and alkalis
Wide Range of Column Sizes: Inner diameter 0.075 - 28mm / Length 10 - 500mm
High Pressure Options
(HP: 500bar / 7,500psi / 50MPa, UP: 1,000bar / 15,000psi / 100MPa)
Metal-Free Column (MF)
MAIN SPECIFICATIONS
| Particle size: | 3μm (Cadenza CD-C18), 5μm (Cadenza 5CD-C18) |
| Base materials: | Fully porous, high-purity silica gel |
| Pore size: | 12nm |
| Ligand: | Octadecyl group |
| End-capping: | Methyl group (polymeric end-capping) |
| Target molecular weight: | Below 10kDa |
| pH Range: | pH 1.5-9 |
| Maximum pressure: | 250bar / 3,500psi / 25MPa HP: 500bar / 7,500psi / 50MPa, UP: 1,000bar / 15,000psi / 100MPa |
| USP Code: | L1 |
Since its inception in 2000, Cadenza CD-C18 has been a leader in the 3μm particle column market. It continues to be one of IMTAKT's flagship products, utilized in over 40 countries worldwide.
The low-pressure, high-theoretical plate column (50,000 plates: 250x4.6mm) still boasts the world's highest theoretical plate number for a 3μm particle column.
Cadenza's Super Column Technology includes:
- Micro-particle column technology honed through the production of 2μm non-porous silica
- Innovative surface structure design with a newly developed stationary phase
- Development of highly reproducible new column manufacturing technology
The development philosophy and manufacturing technology of Cadenza CD-C18 have been continuously passed down to subsequent IMTAKT products.
Notable Applications
- AnaloguesAndrostenedione biosynthetic pathway
- PerformanceFlavonoids in grapefruit juice
- IsomersChloromandelic acid isomers
- AnaloguesOmega-3 and Omega-6 fatty acidsMS
- AnaloguesOmega-3 fatty acid ethyl estersMS
- IsomersEndosulfan isomers (organochlorine pesticide)
- AnaloguesHigh Throughput Reliable Quantitation of 25-hydroxyvitamin D in Serum by Offline Sample Preparation and a LC-MS/MS Instrument
- IsomersAlpha-carotene and beta-carotene
- PerformanceFat-Soluble Vitamins
- Performancecycloamylose (cyclic alpha-1,4-glucan)
- PerformancePeptide mappingMS
- PerformanceImpurity detection (Sudan dyes)
- PerformanceImpurity detection (curcumin)
Technical Information
Features of Cadenza CD-C18
- ●Surface Structure and Properties of the Stationary Phase
- ●Advantages of 3μm Columns
- ●Performance of 150 x 4.6mm Columns
- ●Increased Speed with 75 x 4.6mm Columns
- ●Faster Separation of Lipid-Soluble Vitamins D2 and D3
- ●Faster Separation of Water-Soluble Vitamins
- ●Faster Separation of Isomers
- ●High-Speed Separation with Micro Columns
- ●High-Throughput Separation Mode Comparison (Gradient and Isocratic)
- ●Advantages of Ultra-High-Speed Separation with 3μm Particles
- ●Peak Shape of Coordinating Compounds (Column Comparison)
- ●Performance of 150 x 2mm Columns (Column Comparison)
- ●Reproducibility Between Batches of Packing Material
- ●pH Durability
- ●Durability of Gradient Analysis
- ●Features of 250mm Long High Theoretical Plate Columns
Differences Between Cadenza CD-C18 and Unison UK-C18
- ●Differences in Surface Structure of the Stationary Phase
- ●Differences in Basic Interactions
- ●Comparison of Elution Characteristics: High Polar Region to Low Polar Region
- ●Comparison of Elution Characteristics: Highly Polar Compounds
- ●Differences in Retention Behavior Due to Electrostatic Interactions
Applications NEW
Latest Applications
- ● Dichlorofluorescein (Precipitation titration indicator) NEW
- ● Sulfonazo III (Precipitation titration indicator) NEW
- ● Eriochrome Black T (Metal Indicator)
- ● Xylenol Orange (Metal Indicator)
- ● Hydroxysulfo-naphthylazo-naphthoic Acid (NN, Metallochromic Indicator)
- ● Pyridylazonaphthol (PAN, Metallochromic Indicator)
- ● Thiazolylazonaphthol (TAN, Metallochromic Indicator)
- ● Anisaldehyde isomers
- ● Cromolyn (Antiallergic agent)
- ● Crotamiton (Antipruritic)
- ● Trimethylpyridinium Toluenesulfonate (Condensed Organic Catalyst)
- ● Octyl (Thio)glucoside (Membrane Protein Solubilizing Agent)
- ● Andrographolide(diterpene lactone)
- ● (Diphenylphosphoryl)methylphenol (Condensed Organic Catalyst)
- ● Alizarin, Purpurin (Dye)
- ● Enzalutamide (Antineoplastic) and synthetic intermediate
- ● Statins (HMG-CoA reductase inhibitors) MS
- ● Canrenoic acid (Aldosterone antagonist) MS
- ● Lovastatin (Hypolipidemic agent)
- ● Mevastatin (Lipid-lowering agent)
- ● Zeranol (Growth stimulant), zearalenone (mycotoxin) MS
- ● Carminic acid (Cochineal dye) MS
- ● Gemfibrozil (Hypolipidemic agent) MS
- ● Alpha-lipoic acid (Thioctic Acid, Antioxidants) MS
- ● Zeranol (Growth stimulant) , Zearalenone (Mycotoxin)
- ● Bisphenol A, diethylstilbestrol (Endocrine disrupter) MS
- ● Erythromycin analogues (Antibiotics) MS
- ● Donor building block for organic semiconductor (Dibromocarbazole analogues)
- ● Flonicamid (Pyridine carboxamide pesticides) MS
- ● Nitrofurantoin (5-Nitrofuran antibacterial) MS
- ● tert- Butylphenol isomers MS
- ● Triclocarban, triclosan (Chlorophenyl derivatives) MS
- ● Meropenem (Carbapenem antibiotic) MS
- ● Aztreonam (Monobactam antibiotic) MS
- ● Herbicides (Diuron, Prometryn) MS
- ● Penicillin antibiotics MS
- ● Antiparasitic drugs (Eprinomectin, Ivermectin) MS
- ● Anti-inflammatory drugs MS
- ● Red yeast rice extract (Lovastatin, monacolin K) MS
- ● Bacitracin (polypeptide antibiotic) MS
- ● Cephem antibiotics MS
- ● Aminoglycoside antibiotics (2) MS
- ● Aminoglycoside antibiotics (1) MS
- ● Sulfonamides MS
- ● Antiprotozoal agents MS
- ● Butylated Hydroxytoluene (BHT, Antioxidant) MS
- ● Cannabinoids (CBD, THC) MS
- ● Ethoxyquin (Antioxidant) MS
- ● [Mycotoxins: Aflatoxins G1, G2, B1, B2] MS
- ● [Mycotoxins] Aflatoxins, Fumonisins, Ochratoxins, etc. MS
- ● Spinosad (Naturally Derived Insecticide) MS
- ● Imidacloprid Compounds (Neonicotinoid Insecticides) MS
- ● Pesticides (3) MS
- ● Pesticides (2) MS
- ● Pesticides (1) MS
- ● Vitamin B12 (Cyanocobalamin)
- ● Cholanic acids
- ● Usnic Acid (Aromatic polyketide)
- ● Methylcobalamin (Coenzyme form of Vitamin B12)
- ● Evodiamine (Alkaloid)
- ● Bergapten (Furanocoumarin)
- ● 7-Ethylcamptothecin (Camptothecin derivative)
- ● Capsaicin (Capsaicinoid)
- ● Aloe emodin (Stimulant laxative)
- ● Chrysazin (Contact laxatives)
- ● Flavokawain A (Chalcones)
- ● Monocyclic pyrans (Koji fermentation metabolites)
- ● Magnolol (neolignan)
- ● Phloretin (Polyphenol)
- ● Puerarin (Isoflavone glycoside)
- ● Purpurin (Dye)
- ● Daidzein (Soybean isoflavone)
- ● Adrafinil[synthetic stimulant] MS
- ● [Tyrosinase inhibitor] Rhododendrol
- ● [Sesame lignan] Sesamol
- ● Musty odor compounds in drinking water MS
- ● Indigo (Dye, Pigment)
- ● Methylphenylboronic acid isomers
- ● Trimebutine (Stomach medicine)
- ● Bezafibrate (Hypolipidemic agent)
- ● Melatonin related compounds MS
- ● Melatonin related compounds
- ● Sulfasalazine (Antirheumatic)
- ● 3,3'-Diaminobenzidine
- ● Entacapone (Antiparkinsonian)
- ● Bilirubin (Heme metabolite)
- ● Cycloheximide (Glutarimide antibiotics) MS
- ● Celecoxib (Nonsteroidal anti-inflammatory drug) - neutral pH
- ● Celecoxib (Nonsteroidal anti-inflammatory drug) - acidic pH
- ● Bisacodyl (Laxative) - neutral pH
- ● Bisacodyl (Laxative)- acidic pH
- ● Cyclosporin A (Antibiotics) MS
- ● Nisin, Natamycin (Food preservatives) MS
- ● Isothiazolinone antibiotics
- ● Amphenicol antibiotics
- ● Pitavastatin (Hypolipidemic agent)
- ● Aminophenazone (Anti-inflammatory)
- ● Pemafibrate (Antihyperlipidemic) MS
- ● Pemafibrate (Antihyperlipidemic)
- ● Olmesartan medoxomil (Antihypertensive)- acidic pH
- ● Trimetazidine (vasodilator)- acidic pH
- ● Coumatetralyl (Coumarin anticoagulant) - neutral pH
- ● Coumatetralyl (Coumarin anticoagulant) - acidic pH
- ● Organophosphorus pesticides 3 MS
- ● Organophosphorus pesticides 2 MS
- ● Organophosphorus pesticides 1 MS
- ● Warfarin (Anticoagulant)
- ● Turmeric powder extract
- ● Neonicotinoid pesticides MS
- ● Paclitaxel (Antineoplastic)
- ● Rebamipide (Gastrointestinal agent)
- ● Aspirin/Lansoprazole (Antithrombotic/Antiulcerative)
- ● Fluvastatin (Hypolipidemic agent)
- ● Edoxaban (Antithrombotic)
- ● prohibited 14 colorings for food (Artificial coloring)
- ● 12 Food Colorings(Food additive)
- ● Teprenone (Antiulcer drugs)
- ● Azoxybenzene (Liquid-crystal materials)
- ● Cinnamon powder extract
- ● Mosapride (gastrointestinal motility agent)
- ● Raloxifene (Osteoporosis agent)
- ● Pioglitazone (Antidiabetic)
- ● Artemisinin and related compounds MS
- ● Chlorthalidone (Antianxiety, GABA-A receptor agonist)
- ● Nisolipin (Antihypertensive, Calcium channel blocker)
- ● Ivermectin (antiparasitic drug) MS
- ● Omarigliptin (Oral antidiabetic drug) MS
User Reports
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●Harvard Medical School, USA
High-resolution LC—MS/MS untargeted "Lipidomics" approach applicable to a wide range of biological samples Comment in the paper: "Cadenza CD-C18 excels in robustness, reproducibility, and longevity."
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●IONICS Mass Spectrometry (PerkinElmer) USA
Reproducibility of 5000 analyses of testosterone and 17—hydroxyprogesterone using IONICS BO 220 High-throughput parallel analysis of immunosuppressants in whole blood using a coaxial flow ion source LC-MS/MS system with ESI/ESI dual probes Rapid and simple LC—MS/MS analysis of pain relievers in urine Highly sensitive LC-MS/MS analysis of 25-hydroxyvitamin D3 in serum using offline pretreatment with a multi-mode ODS stationary phase evaluation test mix
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●SCIEX, USA
Rapid Identification of Metabolites Using MetabolitePilot Software and the Triple TOF 5600 System Identification of Reactive Metabolites by High-throughput Scanning Linear Ion Trap
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●Huntingdon Life Sciences, USA
Plasma Cholesterol Analysis Concerning Ion Suppression in LC-MS
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●Tsuno Food Industrial Co., Ltd.
Comprehensive Analysis of Functional Components in Rice Bran Oil
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●Tokushima Bunri University
Molecular Species Identification of Sphingomyelin by LC-MS/MS
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●Shionogi & Co., Ltd.
Ultra-Fast Quantitative Analysis of Drugs in Plasma by LC-MS/MS
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●Yamaguchi Environmental Health Center
Residual Pesticide Testing by LC-MS/MS
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●Shimadzu Corporation
Analysis of Proteins and Peptides by LC-MS Analysis of Aflatoxins by LC-MS
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●Wakayama Pharmaceutical Association
Pesticide Analysis by LC-MS/MS
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●Takara Bio Inc.
Remarkable Differences in Column Injection Volume