Life Sciences Separation Column
World's First Silica-Based Untargeted Organic Acid LC-MS Column
FEATURES
Allows LC-MS analysis of organic acids without derivatization
Capable of analyzing organic acids other than carboxylic acids and inorganic acids (*)
General organic acids can be measured within 10 minutes
Columns for high-throughput analysis in less than 1 minute are also available
In recent years, we have developed a groundbreaking analysis column that enables convenient and selective organic acid analysis using widely adopted universal LC-MS technology. This column represents the world's first silica-based dedicated column for organic acid analysis. By eliminating the need for complex derivatization, most organic acids can be analyzed via LC-MS within 10 minutes.
Introducing ion ligands onto the silica substrate allows highly polar organic acids to be eluted in ion-exchange mode. Using normal-phase mode, even strongly acidic polyacids can be eluted.
This column enables the analysis not only of organic acids but also of phosphate compounds like inorganic phosphoric acids and ATP.
(*)CAUTION
This product is a column for the analysis of organic acids specifically designed for LC-MS applications.
Due to the necessity of gradient elution, UV detectors and conductivity detectors cannot be used.
ELSD is also not recommended due to difficulties in substance identification.
This product does not guarantee the analysis of all organic acids including isomers. Zwitterionic compounds such as amino acids are not within the scope.
Analytical sensitivity depends on compound structure and mass spectrometry performance. Particularly, desolvation temperature affects MS sensitivity.
Peak shapes may be influenced by sample matrix effects. It is necessary to optimize sample pretreatment, sample dissolution solvents, and mobile phase conditions.
The guard column is not metal-free. Guard columns are not recommended for compounds exhibiting ion suppression or coordination effects.
Technical Information
Applications NEW
Carboxylic acids
- ● General Organic Acids (Ion-Exchange Mode)
- ● Polyacids and Polycarboxylic Acids (Normal-phase Mode)
- ● TCA Cycle (Citric Acid Cycle)
- ● Citric acid and hydroxycitric acid
- ● Trimellitic acid isomers NEW
- ● Threonic acid
- ● Hydroxypicolinic acid isomers
- ● Acetic acid (Short-fatty acids)
- ● Canrenoic acid
- ● Alpha-lipoic acid
- ● Chelidonic acid
- ● Cholanic acids
- ● Furan-carboxylic acid
- ● Triterpenic acids
- ● Chloromandelic Acid Isomers
- ● Tyrosinemia Type 1 Related Compounds (Succinylacetone)
- ● Mucic Acid (Galactaric Acid, Mucic Acid)
- ● Oxalic Acid
- ● Hydroxycarboxylic Acids
- ● Simultaneous Analysis of Acetic Acid and Glycolic Acid
- ● Food Preservatives
- ● Plant Hormones - Provided by Dr. Kuwata, Nagoya University
- ● Perm Solution Components (Glycolic Acid, Dithioglycolic Acid, etc.)
- ● Styrene Metabolites (Mandelic Acid, Phenylglyoxylic Acid)
- ● Gemfibrozil (Hypolipidemic agent)
Fatty acids
Sugar acids and uronic acids
Phosphoric compounds
- ● Organophosphorus, quaternary ammonium and bis-guanidine herbicides / fungicides
- ● Ultra-Sensitive (ppt) LC-MS/MS Analysis of Glyphosate, Glufosinate, MPPA, N-Acetyl Glyphosate
- ● Organophosphorus Pesticides (Phosphinic Acid, Ethephon, Hosetyl, Phosphonic Acid, Phosphoric Acid)
- ● Organophosphorus Pesticides (Glyphosate, Glufosinate and Metabolites AMPA, MPPA)
- ● Organophosphorus Pesticides (Bialaphos, Glyphosate)
- ● Rapid Analysis of Organophosphorus Pesticides (Glyphosate, etc.)
- ● Beta-nicotinamide mononucleotide (NMN)
- ● Inosinate, Guanylate
- ● Coenzyme A and acetyl coenzyme A
- ● Cyclic Mononucleotides
- ● Nucleoside Triphosphates (150x2mm)
- ● Nucleoside Triphosphates (250x2mm)
- ● Adenosine Phosphate (AMP, ADP, ATP) Recommended
- ● Adenosine Nucleotides (AMP, ADP, ATP) and Phosphate
- ● Cofactors (NAD/NADH, NADP/NADPH)
- ● Deoxyoligonucleotide (100μL Injection)
- ● Deoxyoligonucleotide d(pT) (50x2mm)
- ● Deoxyoligonucleotide d(pT) (100x2mm)
- ● Deoxyoligonucleotide d(pT) (150x2mm)
- ● Alkyl Phosphonic Acid Esters and Alkyl Phosphonates
- ● Isomers of Sugar Phosphates
- ● Sugar Phosphates (G6P, M6P, F6P, G1P, Gal-1-P, F1P, FBP)
- ● Phytic Acid (Inositol 6-Phosphate)
- ● Phosphorylated Amino Acids (Phosphoserine, Phosphotyrosine, Phosphothreonine)
- ● Fosfomycin (Neurostimulant)
- ● Citicoline (psychostimulant)
- ● Tenofovir (Antiviral)
- ● Bisphosphonates (Medronic Acid, Etidronic Acid)
- ● Bisphosphonate-based Osteoporosis Drugs
Sulfonic acids
- ● Methanesulfonic acids
- ● Azulene sulfonic acid (Nonsteroidal anti-inflammatory drug)
- ● Anthraquinonesulfonic acids (Organic Redox-Flow Battery negative electrolyte)
- ● Dioctyl slufosuccinate (Double-tail anionic surfactant)
- ● Furan-sulfonic acid
- ● Aminonaphtholsulfonic acid isomers
- ● Hydroxybenzenedisulfonic acids
- ● Aryl and Alkyl Disulfonic Acids
- ● Dorzolamide (Vasoprotective Drug)
- ● Sucralfate (Gastric Ulcer Treatment)
- ● Sulfonic Acids, Sulfates
- ● Alcohol Intake Biomarkers (Ethyl Glucuronide [EtG],Ethyl Sulfate [EtS])
Other acids
Organic acids and their counterpart organic compounds
Actual Sample Data
Applications for Actual Samples