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Technical Information   Posters   Papers

Application #:
TI0J21
Type:
Application Note
Categories:
Column Performance
Industrial Chemical
Compounds:
tris (2,2'-bipyridyl) ruthenium (II) chloride hexahydrate
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Tris (2,2'-bipyridyl) ruthenium (II) (Dye for dye sensitized solar cell)

Application #:
TI0I52
Type:
Application Note
Categories:
Industrial Chemical
LC-MS
Compounds:
anthraquinone-1,5-disulfonic acid sodium salt
anthraquinone-1,8-disulfonic acid sodium salt
anthraquinone-1-sulfonic acid sodium salt
Column(s):
Scherzo SW-C18 (150 x 2.0mm)

LC-MS: Organic Redox-Flow Battery negative electrolyte (anthraquinonesulfonic acids)

Application #:
TI0I41
Type:
Application Note
Categories:
Column Performance
Industrial Chemical
Compounds:
1,1'-dimethyl-4,4'-bipyridinium dichloride
1,1'-diethyl-4,4'-bipyridinium dibromide
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Organic Redox-Flow Battery negative electrolyte (Methylviologen dichloride, Ethylviologen dibromide)

Application #:
TI0I40
Type:
Application Note
Categories:
Column Performance
Industrial Chemical
Compounds:
1,1'-dimethyl-4,4'-bipyridinium dichloride
1,1'-diethyl-4,4'-bipyridinium dibromide
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Organic Redox-Flow Battery negative electrolyte (Methylviologen dichloride, Ethylviologen dibromide)

Application #:
TI0G23
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
gramine
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Gramine (Indole alkaloid)

Application #:
TI0F93
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
LC-MS
Compounds:
calcium folinate
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: Folinic acid (Antifolate)

Application #:
TI0F83
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
calcium folinate
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Folinic acid (Antifolate)

Application #:
TI0F61
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
tenofovir
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Tenofovir (Antiviral)

Application #:
TI0E98
Type:
Application Note
Categories:
Column Performance
Industrial Chemical
Compounds:
2-aminophenylboronic acid
3-aminophenylboronic acid
4-aminophenylboronic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Aminophenylboronic acid

Application #:
TI0E68
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
dobesilate
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Dobesilate (Vasoprotectives)

Application #:
TI0E60
Type:
Application Note
Categories:
Food Chemistry
Industrial Chemical
Biochemistry/Metabolism
LC-MS
Compounds:
mandelic acid
phenylglyoxylic acid
Column(s):
Scherzo SW-C18 (100 x 3.0mm)

LC-MS: Styrene urinary metabolites

Application #:
TI0E58
Type:
Application Note
Categories:
Column Performance
Food Chemistry
Industrial Chemical
Biochemistry/Metabolism
Compounds:
mandelic acid
phenylglyoxylic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Styrene urinary metabolites

Application #:
TI0E46
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
adrenaline (epinephrine)
lidocain
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Adrenaline, lidocain (Local anesthetics)

Application #:
TI0D88
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
pinaverium
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Pinaverium (Antispasmodic)

Application #:
TI0D83
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
2-chloronicotinic acid
5-chloronicotinic acid
6-chloronicotinic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Chloronicotinic acid isomers

Application #:
TI0D78
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
5-aminosalicylic acid (mesalazine)
3-aminosalicylic acid
4-aminosalicylic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Mesalazine (Anti-inflammatory) and isomers

Application #:
TI0D62
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
ganciclovir
aciclovir
Column(s):
Scherzo SW-C18 (150 x 4.6mm)
Scherzo SM-C18 (150 x 4.6mm)
Scherzo SS-C18 (150 x 4.6mm)

Ganciclovir, Aciclovir (Antiviral)

Application #:
TI0D39
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
carbazochrome sodium sulfonate
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Carbazochrome (Hemostatic)

Application #:
TI0D38
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
carbazochrome
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Carbazochrome (Hemostatic)

Application #:
TI0D30
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
edoxaban
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Edoxaban (Anticoagulants)

Application #:
TI0D13
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
diphenadione
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Diphenadione (Indandione Anticoagulant)

Application #:
TI0C53
Type:
Application Note
Categories:
Environmental and Agricultural
LC-MS
Compounds:
acephate
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: Acephate

Application #:
TI0B93
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
fexofenadine
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Fexofenadine (Allergic rhinitis, Opioid receptor agonist)

Application #:
TI0B84
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
picosulfate
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Picosulfate (Laxative)

Application #:
TI0B76
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
tranexamic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Tranexamic acid (Anti-inflammatory)

Application #:
TI0B75
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
glycyrrhizic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Glycyrrhizic acid (Anti-inflammatory)

Application #:
TI0B68
Type:
Application Note
Categories:
Column Performance
Environmental and Agricultural
LC-MS
Compounds:
chlormequat chloride
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

LC-MS: Chlormequat (Plant growth retardant)

Application #:
TI0B67
Type:
Application Note
Categories:
Column Performance
Environmental and Agricultural
LC-MS
Compounds:
chlormequat chloride
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

LC-MS: Chlormequat (Plant growth retardant)

Application #:
TI0B61
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
amlodipine
benzenesulfonic acid
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Amlodipine besilate (Antidepressant)

Application #:
TI0B10
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
enoxacin
ciprofloxacin
enrofloxacin
ofloxacin
lomefloxacin
oxolinic acid
norfloxacin
danofloxacin
Column(s):
Scherzo SW-C18 (150 x 4.6mm)

Fluoroquinolones

Application #:
TI0A94
Type:
Application Note
Categories:
Column Performance
Biochemistry/Metabolism
Saccharides
LC-MS
Amino Acids and Peptides
Compounds:
fructosevaline (fructosylvaline)
fructoselysine (fructosyllysine)
pentosidine
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: HbA1c and AGEs related amadori compounds

Application #:
TI0A91
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
metformin
Column(s):
Scherzo SW-C18 (100 x 4.6mm)
Scherzo SM-C18 (100 x 4.6mm)
Scherzo SS-C18 (100 x 4.6mm)

Oral hypoglycemic drug (metformin)

Application #:
TI0A87
Type:
Application Note
Categories:
Column Performance
Biochemistry/Metabolism
LC-MS
Compounds:
1,4-diazabicyclo[2.2.2]octane diazabicyclooctane (DBO)
1,5-diazabicyclo[4.3.0]non-5-ene diazabicyclononene (DBN)
1,8-diazabicyclo[5.4.0]undec-7-ene diazabicycloundecene (DBU)
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: Strong organic base catalysts

Application #:
TI0A86
Type:
Application Note
Categories:
Column Performance
Industrial Chemical
DNA Related Compounds
Biochemistry/Metabolism
LC-MS
Compounds:
imidazole
2-methylimidazole
1-methylimidazole
4-methylimidazole
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: Methylmidazole isomers

Application #:
TI0A75
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
LC-MS
Compounds:
mesylic acid (methanesulfonic acid)
nelfinavir
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

LC-MS: Nelfinavir mesylate (antiretroviral drug)

Application #:
TI0A72
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
LC-MS
Compounds:
maleic acid
chlorpheniramine
Column(s):
Scherzo SW-C18 (100 x 3.0mm)
Scherzo SM-C18 (100 x 3.0mm)
Scherzo SS-C18 (100 x 3.0mm)

LC-MS: Chlorpheniramne maleate (antihistamine)

Application #:
TI0A62
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
rizatriptan
benzoic acid
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Rizatriptan benzoate (treatment of migraine headaches)

Application #:
TI0A61
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
vancomycin
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Antibiotic (vancomycin)

Application #:
TI0A60
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
tizanidine
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Tizanidine (muscle relaxant)

Application #:
TI0A59
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
tadalafil
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Tadalafil

Application #:
TI0A58
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
eperisone
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Eperisone (antispasmodic)

Application #:
TI0A57
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
etodolac
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SM-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

Etodolac (nonsteroidal anti-inflammatory drug, NSAIDs)

Application #:
TI0877
Type:
Application Note
Categories:
LC-MS
Amino Acids and Peptides
Compounds:
L-gama-glutamyl-L-valyl-glycine
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Scherzo SS-C18 (50 x 3.0mm)

LC-MS: Glutamyl-Valyl-Glycine

Application #:
TI0849
Type:
Application Note
Categories:
LC-MS
Biochemistry/Metabolism
Amino Acids and Peptides
Compounds:
orexin A
orexin B
Column(s):
Scherzo SW-C18 (50 x 3.0mm)
Unison UK-Phenyl (100 x 3.0mm)

LC-MS: Orexin A and B

Application #:
TI0847
Type:
Application Note
Categories:
LC-MS
Biochemistry/Metabolism
Amino Acids and Peptides
Compounds:
orexin A
orexin B
Column(s):
Scherzo SW-C18 (50 x 3.0mm)

LC-MS: Orexin A and B

Application #:
TI0841
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
doxylamine
risperidone
olanzapine
Column(s):
Scherzo SW-C18 (100 x 3.0mm)

LC-MS: Antipsychotics

Application #:
TI0837
Type:
Application Note
Categories:
LC-MS
Biochemistry/Metabolism
Compounds:
S-(5'-adenosyl)-L-homocysteine (SAH)
S-(5'-adenosyl)-L-methionine (SAM)
Column(s):
Scherzo SW-C18 (50 x 3.0mm)

LC-MS: SAH and SAM

Application #:
TI0832
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
sumatriptan
zolmitriptan
eletriptan
Column(s):
Scherzo SW-C18 (100 x 3.0mm)

LC-MS: antimigraines (selective serotonin agonists)

Application #:
TI0793
Type:
Application Note
Categories:
LC-MS
Amino Acids and Peptides
Compounds:
Gly-Lys-Ile-Arg-Phe
Gly-Lys-Leu-Arg-Phe
Gly-Lys-Nle-Arg-Phe
Column(s):
Scherzo SW-C18 (150 x 2.0mm)

LC-MS: Peptides containing leucine isomers

Application #:
TI0792
Type:
Application Note
Categories:
LC-MS
Saccharides
Food Chemistry
Compounds:
L-alpha-aspartyl-D-phenylalanine methyl ester
L-alpha-aspartyl-L-phenylalanine methyl ester (aspartame)
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

LC-MS: Aspartame and diastereomers

Application #:
TI0791
Type:
Application Note
Categories:
LC-MS
Biochemistry/Metabolism
Environmental and Agricultural
Compounds:
microcystin RR
microcystin YR
microcystin LR
Column(s):
Scherzo SW-C18 (150 x 2.0mm)

LC-MS: Microcystins

Application #:
TI0789
Type:
Application Note
Categories:
LC-MS
Biochemistry/Metabolism
Compounds:
nicotine
anabasine hydrochloride
cotinine
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

LC-MS: Nicotine related compounds (2)

Application #:
TI0788
Type:
Application Note
Categories:
LC-MS
Vitamins
Amino Acids and Peptides
Biochemistry/Metabolism
Compounds:
L-aspartic acid
L-lysine
nicotinic acid
nicotine
anabasine hydrochloride
cotinine
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

LC-MS: Nicotine related compounds (1)

Application #:
TI0731
Type:
Application Note
Categories:
Biochemistry/Metabolism
Compounds:
shikimic acid
L-tyrosine
L-phenylalanine
L-tryptophan
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

The Scherzo SS-C18 column provides better retention of Shikimic Acid than a standard C18 column.

Application #:
TI0726
Type:
Application Note
Categories:
Amino Acids and Peptides
Compounds:
angiotensin II (human)
angiotensin IV (human
[val5]-angiotensin I (bovine)
angiotensin I (human)
angiotensin II (human)
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

Oligopeptides (angiotensins)

Application #:
TI0725
Type:
Application Note
Categories:
Amino Acids and Peptides
Biochemistry/Metabolism
Compounds:
angiotensin II (human)
angiotensin IV (human)
[val5]-angiotensin I (bovine)
angiotensin I (human)
angiotensin III (human)
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Oligopeptides (angiotensins)

Application #:
TI0724
Type:
Application Note
Categories:
Amino Acids and Peptides
Compounds:
angiotensin II (human)
angiotensin IV (human
[val5]-angiotensin I (bovine)
angiotensin I (human)
angiotensin II (human)
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Oligopeptides (angiotensins)

Application #:
TI0720
Type:
Application Note
Categories:
Biochemistry/Metabolism
Botanicals
Compounds:
Shikimic acid
malic acid
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

The Scherzo SM-C18 and Scherzo SS-C18 column resolve very polar carboxylic acids that normally co-elute on a standard C18 column (Unison UK-C18).

Application #:
TI0719
Type:
Application Note
Categories:
Biochemistry/Metabolism
Compounds:
Prostaglandin F2
Prostaglandin E2
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

The Scherzo SS-C18 column retains Prostaglandins the most, followed by Scherzo SM-C18 and Scherzo SW-C18.

Application #:
TI0713
Type:
Application Note
Categories:
Industrial chemical
Compounds:
"ethylenediamine
diethylenetriamine
triethylenetetramine (including branched structures)
tetraethylenepentamine (including branched structures)"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

The Scherzo SW-C18 column is able to retain compounds with multiple amine functionalities.

Application #:
TI0703
Type:
Application Note
Categories:
Industrial Chemical
Compounds:
Formic acid and acetic acid
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Scherzo SM-C18 (250 x 3.0mm)
Scherzo SS-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

The Scherzo SM-C18 and SS-C18 show excellent resolution of these small molecules, which normally coelute on a standard C18 column.

Application #:
TI0702
Type:
Application Note
Categories:
Environmental and Agricultural
Compounds:
Arsenobetaine
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

The Scherzo SS-C18 column shows improved resolution of arsenobetaine compared to a standard C18 column. The Scherzo SM-C18 and the Scherzo SW-C18 show similar retention of this zwitterion as the standard Unison UK-C18 column.

Application #:
TI0701
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Botanicals
Biochemistry/Metabolism
Compounds:
Allantoin
allantoic acid and uric acid
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Scherzo SM-C18 (250 x 3.0mm)
Scherzo SS-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

The Scherzo SM-C18 and the Scherzo SW-C18 show similar retention of these small molecules as the standard Unison UK-C18. However, the Scherzo SS-C18 shows the best resolution between these three compounds.

Application #:
TI0700
Type:
Application Note
Categories:
Saccharides
Amino Acids and Peptides
Compounds:
Sialylglycopeptide
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Scherzo SM-C18 (250 x 3.0mm)
Scherzo SS-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

The Scherzo family columns can separate this glycopeptide with varying retention. The Scherzo SW-C18 has the least retention, followed by the Scherzo SM-C18, followed by the Scherzo SS-C18 which has the most retention.

Application #:
TI0699
Type:
Application Note
Categories:
Saccharides
Amino Acids and Peptides
Compounds:
Sialylglycopeptide
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Scherzo SM-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

The Scherzo SM-C18 and SW-C18 columns can separate this glycopeptide with varying retention. The Scherzo SM-C18 has less retention while the Scherzo SW-C18 has more retention.

Application #:
TI0692
Type:
Application Note
Categories:
Food Chemistry
Compounds:
hydroxyhydroquinone
3,4-dihydroxyhydrocinnamic acid
caffeic acid
p-coumaric acid
caffeine
ferulic acid
isoferulic acid
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

Both Unison UK-C18 and Scherzo SW-C18 can separate out components of coffee extracts, but Scherzo SW-C18 can resolve the peaks of caffeine and ferulic acid better.

Application #:
TI0691
Type:
Application Note
Categories:
Biochemistry/Metabolism
Compounds:
AMP
ADP
ATP
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

The highly charged phosphate groups make separation of AMP, ADP, and ATP difficult on a conventional C18 column. Scherzo SW-C18 is able to elute these compounds effectively, in both ammonium acetate and ammonium phosphate buffers.

Application #:
TI0690
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
Ibuprofen
Chlorpheniramine
Column(s):
Scherzo SW-C18 (150 x 4.6mm)
Scherzo SM-C18 (150 x 4.6mm)

Both Scherzo SM-C18 and Scherzo SW-C18 can separate an acidic compound (Ibuprofen) and a basic compound (Chlorpheniramine) at the same time. Scherzo SW-C18 works better under gradient elution, whereas Scherzo SM-C18 works better under isocratic elution.

Application #:
TI0683
Type:
Application Note
Categories:
Biochemistry/Metabolism
Compounds:
"5-hydroxy-L-tryptophan
serotonin
L-tryptophan
5-hydroxyindole -3-acetic acid (5-HIAA)"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

Serotonin related compounds

Application #:
TI0680
Type:
Application Note
Categories:
DNA Related Compounds
Compounds:
oligothymidylic acid d(pT) ammonium salt
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

Oligonucleotides

Application #:
TI0679
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
" acetaminophen
N-acetyl-4-benzoquinone imine"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Acetaminophen and metabolite

Application #:
TI0678
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
" acetaminophen
N-acetyl-4-benzoquinone imine"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Acetaminophen and metabolite

Application #:
TI0673
Type:
Application Note
Categories:
DNA Related Compounds
Compounds:
siRNA Universal Negative Control
Control siRNA
Negative Control
Control siRNA duplex (Human cdk1)
Control siRNA duplex (Human beta-actin)
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

siRNA

Application #:
TI0672
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
phenylephrine
N-acetylprocainamide
procaine
naphazoline
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

Basic pharmaceutical compounds

Application #:
TI0669
Type:
Application Note
Categories:
Biochemistry/Metabolism
Pharmaceuticals and Cosmetics
Compounds:
gamma-aminobutyric acid (GABA)
D,L-noradrenaline ((D,L-norepinephrine)
D,L-adrenaline (D,L-epinephrine)
3,4-dihydroxy-L-phenylalanine (L-DOPA)
dopamine
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

Catecholamines

Application #:
SP0042
Type:
Poster
Categories:
Column Performance
Biochemistry/Metabolism
Vitamins
LC-MS
Amino Acids and Peptides
Compounds:
17 alpha-hydroxyprogesterone
glucosamine-6-phosphate
cytosine
octopamine
GABA
hypotaurine
glycine
kynurenine
methionine
arginosuccinic acid
cysteine sulfinic acid
AMP
adenosine
thiamine
ornithine
arginine
alanine
aspartic acid
myo-inositol
glutamic acid
histidine
5-HIAA
lyso-sulfatide
cytidine
isoleucine
1-methylhistidine
3-methylhistidine
S-adenosylhomocystein
glutamine
tyrosine
glycylglycine
valine
cortisone
cAMP
biopterin
tryptophan
3-hydroxybenzoate
orotic acid
nicotinic acid
Phe-Ala,leucine
glycocholic acid
cholic acid
adenine
DOPA
butyric acid
linolenic acid
indole
p-cresol
Column(s):
Scherzo SW-C18 (100 x 2.0mm)
Scherzo SM-C18 (100 x 2.0mm)
Scherzo SS-C18 (100 x 2.0mm)

A Systematic Approach to Development of Analytical Scale and Microflow-based LC-MS Metabolomics Methods to Support Drug Discovery and Development

Application #:
SP0040
Type:
Poster
Categories:
Column Performance
Compounds:
Column(s):
Intrada Amino Acid (0 x 0.0mm)
Intrada WP-RP (0 x 0.0mm)
Scherzo SW-C18 (0 x 0.0mm)
Scherzo SM-C18 (0 x 0.0mm)
Scherzo SS-C18 (0 x 0.0mm)
Cadenza CD-C18 (0 x 0.0mm)
Cadenza CW-C18 (0 x 0.0mm)
Cadenza CL-C18 (0 x 0.0mm)
Cadenza HS-C18 (0 x 0.0mm)
Unison UK-C18 (0 x 0.0mm)
Unison UK-C8 (0 x 0.0mm)
Unison UK-Phenyl (0 x 0.0mm)
Unison UK-Silica (0 x 0.0mm)
Unison UK-Amino (0 x 0.0mm)
Presto FF-C18 (0 x 0.0mm)
Intrada SEC (0 x 0.0mm)
Dacapo DX-C18 (0 x 0.0mm)
Cadenza CX-C18 (0 x 0.0mm)

Imtakt Product Comparisons: Product Descriptions

Application #:
JA0019
Type:
Paper
Categories:
0
Compounds:
0
Column(s):
Scherzo SW-C18 (150 x 4.6mm)
Scherzo SM-C18 (150 x 4.6mm)
Scherzo SS-C18 (150 x 4.6mm)

Factors influencing the separation of oligonucleotides using reversed-phase/ion-exchange mixed-mode high performance liquid chromatography columns

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